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ORAI1 Monoclonal Antibody#26039

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Product Detail

Product NameORAI1 Monoclonal Antibody

Clone No.mAb (Clone 6D11A11)

Host SpeciesMouse

ClonalityMonoclonal

PurificationImmunoaffinity chromotography purified IgG

ApplicationsELISA WB IHC

Species ReactivityHu Ms Rt

Immunogen TypePeptide

Immunogen DescRaised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.

Target NameORAI1

ConjugateUnconjugated

Other NamesORAI1 (6D11A11), Transmembrane protein 142A, TMEM142A, Calcium release-activated calcium channel protein 1

Accession NoSwiss-Prot:Q96D31
Gene ID:84876

Uniprot Q96D31

Gene ID 84876;

Concentration1mg/ml

FormulationSupplied in PBS containing 0.02% sodium azide.

StorageCan be stored at -20˚C, stable for one year.

Application Details
Western blot analysis of ORAI1 in human spleen tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/mL.
Immunofluorescence of ORAI1 in rat spleen tissue with ORAI1 antibody at 5 μg/ml.
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

If you have published an article using product 26039, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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