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IRAK Monoclonal Antibody#26041

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Product Detail

Product NameIRAK Monoclonal Antibody

Clone No.mAb (Clone 8F1A7)

Host SpeciesMouse

ClonalityMonoclonal

PurificationImmunoaffinity chromotography purified IgG

ApplicationsELISA WB IHC

Species ReactivityHu Ms

Immunogen TypeRecombinant protein

Immunogen DescRecombinant protein corresponding to amino acids 618 - 712 of human IRAK.

Target NameIRAK

ConjugateUnconjugated

Other NamesIRAK (8F1A7),IL-1-Receptor Associated Kinase

Accession NoSwiss-Prot:P51617
Gene ID:3654

Uniprot P51617

Gene ID 3654;

Concentration1mg/ml

FormulationSupplied in PBS containing 0.02% sodium azide.

StorageCan be stored at -20˚C, stable for one year.

Application Details
Western blot analysis of IRAK in mouse liver lysate with IRAK antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of IRAK in rat liver tissue with IRAK antibody at 5 ug/mL.
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).

If you have published an article using product 26041, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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