Product Detail
Product NameGPI Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IF
Species ReactivityHuman,Mouse,Rat
Immunogen DescRecombinant fusion protein of human glucose-6-phosphate isomerase (NP_000166.2).
ConjugateUnconjugated
Other NamesGPI;AMF;GNPI;NLK;PGI;PHI;SA-36;SA36
Accession NoUniprot:P06744
GeneID:2821
Uniprot
P06744
Gene ID
2821
Calculated MW56kDa
Sdspage MW56kDa
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using glucose-6-phosphate isomerase antibody.
Immunofluorescence analysis of NIH-3T3 cells using glucose-6-phosphate isomerase antibody.
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.
If you have published an article using product 27978, please notify us so that we can cite your literature.
et al,LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress.
, (2025),
PMID:
39900910
Yes
