Product Detail
Product NamePD-L1 Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IHC,IF
Species ReactivityHuman,Mouse,Rat
Immunogen DescRecombinant fusion protein of human PD-L1 (NP_054862.1).
ConjugateUnconjugated
Other NamesB7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274
Accession NoGeneID:29126
Swiss Prot:Q9NZQ7
Uniprot
Q9NZQ7
Gene ID
29126;
Calculated MW20kDa/33kDa
Sdspage MW45kDa
Concentration1.0mg/ml
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.124.
Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:100
Immunohistochemistry of paraffin-embedded human colon carcinoma using PD-L1 antibody at dilution of 1:100 .
Western blot analysis of extracts of A-549 cells, using PD-L1 antibody at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded mouse spleen using PD-L1 antibody at dilution of 1:100 .
Immunohistochemistry of paraffin-embedded rat spleen using PD-L1 antibody at dilution of 1:100 .
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
If you have published an article using product 29074, please notify us so that we can cite your literature.
et al,Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapyIn Cell Rep.On2023 May 30byQicong Luo , Zinan Dong et al..PMID:37097818
, (2023),
PMID:
37097818
et al,Biodegradable iridium coordinated nanodrugs potentiate photodynamic therapy and immunotherapy of lung cancer.
, (2025),
PMID:
39488900
Yes
