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Location： Home > Polyclonal Antibodies > RUNX2 Rabbit Polyclonal Antibody

RUNX2 Rabbit Polyclonal Antibody#29595

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Product Detail

Product NameRUNX2 Rabbit Polyclonal Antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationAffinity purification

ApplicationsWB IHC IF

Species ReactivityHuman,Mouse,Rat

Immunogen DescRecombinant fusion protein of human RUNX2 (NP_001019801.3).

ConjugateUnconjugated

Other NamesRUNX2;AML3;CBF-alpha-1;CBFA1;CCD;CCD1;CLCD;OSF-2;OSF2;PEA2aA;PEBP2aA

Accession NoSwiss Prot:Q13950
GeneID:860

Calculated MW54kDa/55kDa/56kDa

Sdspage MW70kDa

FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

StorageStore at -20˚C. Avoid freeze / thaw cycles.

Application Details

WB 1:200 - 1:1000

IHC 1:50 - 1:200
IF 1:50 - 1:200

Western blot analysis of extracts of various cell lines, using RUNX2 at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded mouse salivary gland using RUNX2 Rabbit pAb at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

If you have published an article using product 29595, please notify us so that we can cite your literature.

et al,3D printed PGCL@PLA/10CSPL composite scaffolds loaded with fibronectin 1 for intervertebral disc degeneration treatment, In Biofabrication on 2024 Dec 13 by Weilin Zhang, Siyuan Chen,et al..PMID:39668784 , (2024),
PMID: 39668784

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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