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Location： Home > Polyclonal Antibodies > KEAP1 Antibody

KEAP1 Antibody#32450

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Product Detail

Product NameKEAP1 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationAffinity purification

ApplicationsWB,IHC,IF

Species ReactivityHuman,Mouse,Rat

SpecificityThe antibody detects endogenous level of total KEAP1 protein.

Immunogen TypeRecombinant Protein

Immunogen DescRecombinant fusion protein of human KEAP1 (NP_036421.2).

Target NameKEAP1

ConjugateUnconjugated

Other NamesKEAP1;INrf2;KLHL19

Accession NoUniprot:Q14145
GeneID:9817

Uniprot Q14145

Gene ID 9817

Sdspage MW60KDa

Concentration1.0mg/ml

FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.

StorageStore at -20˚C. Avoid freeze / thaw cycles.

Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using KEAP1 antibody.
Immunohistochemistry of paraffin-embedded human colon carcinoma using KEAP1 Rabbit pAb.
Immunofluorescence analysis of U-2 OS cells using KEAP1 Rabbit pAb.
Immunofluorescence analysis of C6 cells using KEAP1 Rabbit pAb.
Immunohistochemistry of paraffin-embedded human esophageal cancer using KEAP1 Rabbit pAb.
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

If you have published an article using product 32450, please notify us so that we can cite your literature.

et al,c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2InMol Biol RepOn2023 AugbyYuxiang Zhao?1,?Yue Wang et al..PMID:?37358765 , (2023),
PMID: 37358765
et al,Association of α-Klotho with regulation of Keap1/Nrf2/Interleukin-1 pathway and AMPA receptor trafficking in the brain of suicide victims. In J Physiol Pharmacol on 2024 Jun by P Panczyszyn-Trzewik, P Misztak,et al..PMID: 39042386 , (2024),
PMID: 39042386

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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