Product Detail
Product NameTIMP1 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous levels of total TIMP1 protein.
Immunogen TypePeptide
Immunogen DescSynthesized peptide derived from internal of human TIMP1.
Target NameTIMP1
ConjugateUnconjugated
Other Namestissue inhibitor of metalloproteinase 1;
Accession NoSwiss-Prot: P01033
NCBI Gene ID: 7076
Uniprot
P01033
Gene ID
7076;
Sdspage MW24kd
Concentration1.0mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
Western blotting: 1:500~1:3000
Western blot analysis of extracts from 293 cells, using TIMP1 antibody #33502.
Western blot analysis of extracts from cos-7 cells (Lane 2), using TIMP1 antiobdy #33502. The lane on the left is treated with synthesized peptide.
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Anieta M. Sieuwerts, Clin. Chem., May 2007; 10.1373.
KM Fong, Clin. Cancer Res., Aug 1996; 2: 1369.
E. Susol, Rheumatology, Dec 2000; 39: 1332 - 1336.
Christopher J Jackson, Ann Rheum Dis, Mar 1998; 57: 158 - 161.
If you have published an article using product 33502, please notify us so that we can cite your literature.
et al,Combination therapy of chitosan, gynostemma, and motherwort alleviates the progression of experimental rat chronic renal failure by inhibiting STAT1 activation.In Oncotarget.On 2018 Mar 20 by Wenxia Bai,1 Shudong Wang et al..PMID: 29643988
, (2018),
PMID:
29643988
et al,TGF β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro.In Environ Toxicol on 2020 Apr by Zhang Q, Chang X ,et al..PMID: 31737983
, (2020),
PMID:
31737983
Yes
