Product Detail
Product NameBAX Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB IHC IF
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous levels of total BAX protein.
Immunogen TypePeptide
Immunogen DescSynthesized peptide derived from internal of human BAX.
Target NameBAX
ConjugateUnconjugated
Other NamesApoptosis regulator BAX; BAX;
Accession NoSwiss-Prot: Q07814
NCBI Gene ID: 581
Uniprot
Q07812
Gene ID
581;
Sdspage MW22kd
Concentration1.0mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Oltvai Z.N., Cell 74:609-619(1993).
Apte S.S., Genomics 26:592-594(1995).
Shi B., Biochem. Biophys. Res. Commun. 254:779-785(1999).
If you have published an article using product 34260, please notify us so that we can cite your literature.
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