Product Detail
Product NameCHP2 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous levels of total CHP2 protein.
Immunogen TypePeptide
Immunogen DescSynthesized peptide derived from internal of humanCHP2.
Target NameCHP2
ConjugateUnconjugated
Other NamesCalcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520; CHP2; HCA520;
Accession NoSwiss-Prot: O43745
NCBI Gene ID: 63928
Uniprot
O43745
Gene ID
63928;
Sdspage MW22kd
Concentration1.0mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
Western blotting: 1:500~1:3000
Western blot analysis of extracts from Jurkat cells, K562 cells and HT-29 cells, using CHP2 antibody.The lane on the right is treated with synthesized peptide
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
Loftus B.J., Genomics 60:295-308(1999).
Wang Y., J. Immunol. 169:1102-1109(2002).
Pang T., J. Biol. Chem. 277:43771-43777(2002).
If you have published an article using product 34512, please notify us so that we can cite your literature.
et al,CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a.In Mol Cancer Res.On 2018 Oct by Zhao X, Xie T et al..PMID: 29967111
, (2018),
PMID:
29967111
Yes
