Product Detail
Product NameIFIT5 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total IFIT5 protein.
Immunogen TypePeptide
Immunogen DescSynthesized peptide derived from internal of human IFIT5.
Target NameIFIT5
ConjugateUnconjugated
Other NamesIFIT-5; interferon-induced protein with tetratricopeptide repeats 5; retinoic acid- and interferon-inducible 58 kDa protein; RI58;
Accession NoSwiss-Prot: Q13325
NCBI Gene ID: 24138
Uniprot
Q13325
Gene ID
24138;
Sdspage MW50kd
Concentration1.0mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
Western blotting: 1:500~1:3000
Western blot analysis of extracts from Jurkat cells, using IFIT5 antibody #35225.
Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.
Rogers J., Nature 429:375-381(2004).
Venter J.C., Submitted (SEP-2005).
Bennett K.L., Submitted (OCT-2008).
If you have published an article using product 35225, please notify us so that we can cite your literature.
et al,NF-κB-Dependent IFIT3 Induction by HBx Promotes Hepatitis B Virus Replication. In Front Microbiol on 2019 Oct 11 by Xu F, Song H, et al..PMID:31681236
, (2019),
PMID:
31681236
Yes
