Product Detail
Product Namep38 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were purified by antigen-affinity chromatography.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total p38 protein.
Immunogen TypeRecombinant Protein
Immunogen DescRecombinant fragment contain a sequence corresponding to a region within amino acids 1 and 310 of p38 alpha.
Target Namep38
ConjugateUnconjugated
Other NamesCSBP antibody; CSBP1 antibody; CSBP2 antibody; CSPB1 antibody; EXIP antibody; Mxi2 antibody; PRKM14 antibody; PRKM15 antibody; RK antibody; SAPK2A antibody; p38 antibody; p38ALPHA antibody; MAPK14 antibody; mitogen-activated protein kinase 14 antibody; Cs
Accession NoSwiss-Prot#:Q16539;
NCBI Gene#:1432
Uniprot
Q16539
Gene ID
1432;
Sdspage MW41kd
Concentration0.64mg/ml
FormulationRabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
StorageStore at -20˚C
Application Details
Western blotting: 1:500-1:3000
Sample (30 ug of whole cell lysate)
A: 293T
B: HepG2
C: Molt-4
10% SDS PAGE
#35478 diluted at 1:1000
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
If you have published an article using product 35478, please notify us so that we can cite your literature.
et al,Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules
, (2021),
PMID:
Yes
