Product Detail
Product NameUSP2 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntigen affinity purification.
ApplicationsIHC
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total USP2 protein.
Immunogen TypeRecombinant Protein
Immunogen DescFusion protein corresponding to residues near the C terminal of human ubiquitin specific peptidase 2
Target NameUSP2
ConjugateUnconjugated
Other NamesUSP9; UBP41
Accession NoSwiss-Prot#: O75604
NCBI Gene ID: 9099
Gene Accssion: BC002854
Uniprot
O75604
Gene ID
9099;
Concentration1.7mg/ml
FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
StorageStore at -20˚C
Application Details
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using #36169 at dilution 1/40.
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36169 at dilution 1/40.
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
If you have published an article using product 36169, please notify us so that we can cite your literature.
et al,Roxadustat ameliorates experimental colitis in mice by regulating macrophage polarization through increasing HIF level. In Biochim Biophys Acta Gen Subj on 2024 Mar by Guiping Kong, Hu Hua,et al..PMID:38158022
, (2024),
PMID:
38158022
Yes
