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MC1R Antibody#36969

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Product NameMC1R Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ApplicationsWB

Species ReactivityHu Ms

SpecificityThe antibody detects endogenous levels of total MC1R protein.

Immunogen TypePeptide

Immunogen DescThe antiserum was produced against synthesized peptide derived from human MSHR.

Target NameMC1R

ConjugateUnconjugated

Other NamesCMM5; MSH-R; SHEP2

Accession NoSwiss-Prot#: Q01726
NCBI Gene ID: 4157
Gene Accssion: NP_002377

Uniprot Q01726

Gene ID 4157;

Sdspage MW35kd

Concentration1.0 mg/ml

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

StorageStore at -20˚C

Application Details

Western blotting: 1:500-1:2000

Western Blot analysis of COLO205 cells using MC1-R Polyclonal Antibody

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.?

If you have published an article using product 36969, please notify us so that we can cite your literature.

et al,Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia. In PLoS Biol on 2024 Dec 2 by Xiaoyu Tian, Hanyu Wang,et al..PMID:39621784 , (2024),
PMID: 39621784

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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