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CAV1 Antibody#37401

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Product Detail

Product NameCAV1 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification.

ApplicationsWB IHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous levels of total CAV1 protein.

Immunogen TypePeptide

Immunogen DescSynthetic peptide corresponding to residues near the N terminal of human caveolin 1, caveolae protein, 22kDa

Target NameCAV1

ConjugateUnconjugated

Other NamesCGL3; PPH3; BSCL3; VIP21; MSTP085

Accession NoSwiss-Prot#: Q03135
NCBI Gene ID: 857
Gene Accssion: NP_001744

Uniprot Q03135

Gene ID 857;

Sdspage MW20kd

Concentration2.2mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details
Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:50-1:200
Gel: 10%SDS-PAGE
Lysates (from left to right): Human fetal muscle and fetal lung tissue, human leiomyosarcoma tissue, mouse lung and heart tissue, NIH/3T3 cell
Amount of lysate: 40ug per lane
Primary antibody: 1/550 dilution
Secondary antibody dilution: 1/8000
Exposure time: 10 seconds
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #37401 at dilution 1/40.
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

If you have published an article using product 37401, please notify us so that we can cite your literature.

et al,PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing.In Cell Death Dis.On 2018 May 1 by PMID: 29752441 , (2018),
PMID: 29752441

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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