Product Detail
Product NamePOMC antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were purified by affinity purification using immunogen.
ApplicationsWB
Species ReactivityHuman,Mouse,Rat
SpecificityThe antibody detects endogenous level of total POMC protein.
Immunogen TypePeptide
Immunogen DescA synthetic peptide of human POMC.
Target NamePOMC
ConjugateUnconjugated
Other NamesLPH; MSH; NPP; POC; ACTH; CLIP
Accession NoSwiss-Prot#: P01189
NCBI Gene ID: 5443
Uniprot
P01189
Gene ID
5443;
Sdspage MW29kd
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using POMC at 1:1000 dilution.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.
If you have published an article using product 38547, please notify us so that we can cite your literature.
et al,Xiaoyaosan decoction regulates food Intake and body weight via the leptIn-leptIn receptor-proopiomelanocortIn pathway In rats with chronic immobilization stress. In J Tradit ChIn Med on 2019 Feb by Wang X, Fang C,et al..PMID:32186021
, (2019),
PMID:
32186021
The lead time is currently 2 weeks.
