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Location： Home > Recombinant Rabbit Monoclonal Antibodies > LRP1 Rabbit mAb

LRP1 Rabbit mAb#48595

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Product Detail

Product NameLRP1 Rabbit mAb

Clone No.SA0290

Host SpeciesRecombinant Rabbit

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesA2MR antibody
Alpha 2 macroglobulin receptor antibody
alpha 2MR antibody
Alpha-2-macroglobulin receptor antibody
APOER antibody
Apolipoprotein E receptor antibody
APR antibody
CD 91 antibody
CD91 antibody
CD91 antigen antibody
IGFBP3R antibody
LDL receptor related protein 1 antibody
Low density lipoprotein receptor related protein 1 antibody
Low density lipoprotein related protein 1 antibody
Low-density lipoprotein receptor-related protein 1 intracellular domain antibody
LRP 1 antibody
LRP 515 antibody
LRP 85 antibody
LRP antibody
LRP ICD antibody
LRP-1 antibody
LRP-515 antibody
LRP-85 antibody
Lrp1 antibody
LRP1 protein antibody
LRP1_HUMAN antibody
LRP1A antibody
LRP515 antibody
LRP85 antibody
LRPICD antibody
MGC88725 antibody
Prolow density lipoprotein receptor related protein 1 antibody
TbetaR V/LRP 1/IGFBP 3 receptor antibody
TbetaRV/LRP1/IGFBP3 receptor antibody
TGFBR 5 antibody
TGFBR5 antibody
Type V tgf beta receptor antibody

Accession NoSwiss-Prot#:Q07954

Uniprot Q07954

Gene ID 4035;

Calculated MW85 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details

WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:10-1:100

Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-LRP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-LRP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-LRP1 antibody. Counter stained with hematoxylin..
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-LRP1 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Hela cells with LRP1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
Western blot analysis of LRP1 on different lysates using anti-LRP1 antibody at 1/1,000 dilution. Positive control:
Lane 1: Mouse liver
Lane 2: Mouse brain Lane
Lane 3: Mouse lung
Lane 4: Human liver
Lane 5: HepG2
Lane 6: Human lung
ICC staining LRP1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS..
ICC staining LRP1 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining LRP1 in HUVEC cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and ?-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including ?-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimers disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

If you have published an article using product 48595, please notify us so that we can cite your literature.

et al,Lactotransferrin Downregulation Drives the Metastatic Progression in Clear Cell Renal Cell Carcinoma. In Cancers (Basel) on 2020 Mar 31 by I-Jen Chiu, Yung-Ho Hsu, et al..PMID: 32244557 , (2020),
PMID: 32244557
et al,LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats. , (2025),
PMID: 39674403

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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