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Integrin alpha 6 Rabbit mAb#48626

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Product Detail

Product NameIntegrin alpha 6 Rabbit mAb

Clone No.SR45-00

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesAlpha6p antibody
CD49 antigen-like family member F antibody
CD49f antibody
Integrin alpha6B antibody
Integrin, alpha 6 antibody
ITA6_HUMAN antibody
ITGA6 antibody
ITGA6B antibody
Processed integrin alpha-6 antibody
VLA 6 antibody
VLA-6 antibody

Accession NoSwiss-Prot#:P23229

Uniprot P23229

Gene ID 3655;

Calculated MW127 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details

WB: 1:500-1:1,000
IHC: 1:50-1:200
 

Western blot analysis of Integrin alpha 6 on Raji cell lysates using anti-Integrin alpha 6 antibody at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Integrin alpha 6 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Integrin alpha 6 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-Integrin alpha 6 antibody. Counter stained with hematoxylin.

Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

If you have published an article using product 48626, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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