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Location： Home > Recombinant Rabbit Monoclonal Antibodies > SHP1 Rabbit mAb

SHP1 Rabbit mAb#48636

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Product Detail

Product NameSHP1 Rabbit mAb

Clone No.SR41-02

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Names70Z-SHP antibody
EC 3.1.3.48 antibody
HCP antibody
HCPH antibody
Hematopoietic cell phosphatase antibody
Hematopoietic cell protein tyrosine phosphatase antibody
Hematopoietic cell protein-tyrosine phosphatase antibody
HPTP1C antibody
Protein tyrosine phosphatase 1C antibody
Protein tyrosine phosphatase non receptor type 6 antibody
Protein tyrosine phosphatase SHP1 antibody
Protein-tyrosine phosphatase 1C antibody
protein-tyrosine phosphatase SHP 1 antibody
Protein-tyrosine phosphatase SHP-1 antibody
PTN6_HUMAN antibody
PTP 1C antibody
PTP-1C antibody
PTP1C antibody
Ptpn6 antibody
SH PTP 1 antibody
SH PTP1 antibody
SH-PTP1 antibody
SHP 1 antibody
SHP 1L antibody
SHP1 antibody
SHP1L antibody
tyrosine protein phosphatase non receptor type 6 antibody
Tyrosine-protein phosphatase non-receptor type 6 antibody

Accession NoSwiss-Prot#:P29350

Uniprot P29350

Gene ID 5777;

Calculated MW68 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100
Western blot analysis of SHP1 on Raji cell lysates using anti-SHP1 antibody at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-SHP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded rat spleen tissue using anti-SHP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-SHP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-SHP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-SHP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-SHP1 antibody. Counter stained with hematoxylin.
ICC staining SHP1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining SHP1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Hela cells with SHP1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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