Product Detail
Product NameROCK1 Rabbit mAb
Clone No.ST05-19
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC, IP, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Namescoiled-coil-containing protein kinase 1 antibody coiled-coil-containing protein kinase I antibody MGC131603 antibody MGC43611 antibody p160 Rhoassociated coiled coil-forming protein kinase antibody p160 ROCK-1 antibody p160 ROCK1 antibody p160ROCK antibody PRO0435 antibody Renal carcinoma antigen NY REN 35 antibody Renal carcinoma antigen NY-REN-35 antibody Rho associated coiled coil containing protein kinase 1 antibody Rho associated protein kinase 1 antibody Rho kinase antibody Rho-alpha kinase antibody Rho-associated antibody Rho-associated protein kinase 1 antibody ROCK I antibody ROCK-I antibody ROCK1 antibody ROCK1_HUMAN antibody Rok antibody rokalpha antibody
Accession NoSwiss-Prot#:Q13464
Uniprot
Q13464
Gene ID
6093;
Calculated MW158 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:100
Western blot analysis of ROCK1 on different lysates using anti-ROCK1 antibody at 1/1,000 dilution. Positive control: Lane 1: A431 Lane 2: NIH/3T3
Immunohistochemical analysis of paraffin-embedded mouse thyroid tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.
Rho, the Ras-related small GTPase, is responsible for the regulation of Actin-based cytoskeletal structures including stress fibers, focal adhesions and the contractile ring apparatus. Rho proteins function as molecular switches that are able to turn cytokinesis on and off. Although little is known about signaling downstream of Rho, a host of putative Rho effector proteins have been described, including rhophilin, Rhotekin, citron and the serine/threonine kinase, protein kinase N. Two additional Rho-activated serine/threonine kinases have been described, designated Rock-1 and Rock-2 (also referred to as Roka, for Rho-associated coil-containing protein kinase). Rock-1 and Rock-2 share a structural similarity with myotonic dystrophy kinase.
If you have published an article using product 48890, please notify us so that we can cite your literature.
et al,Neferine, a novel ROCK1-targeting inhibitor, blocks EMT process and induces apoptosis in non-small cell lung cancer. In J Cancer Res Clin Oncol on 2022 Aug 19
by Po Hu, Peng Wan, et al..PMID:35984492
, (2022),
PMID:
35984492
Yes
