Product Detail
Product NameIslet 1 Rabbit mAb
Clone No.SC05-64
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IP
Species ReactivityHu, Ms
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesInsulin gene enhancer protein ISL 1 antibody Insulin gene enhancer protein ISL-1 antibody Insulin related protein antibody ISL 1 antibody ISL LIM homeobox 1 antibody ISL1 antibody ISL1 transcription factor LIM homeodomain antibody ISL1 transcription factor, LIM/homeodomain (islet 1) antibody ISL1 transcription factor, LIM/homeodomain antibody ISL1_HUMAN antibody Islet-1 antibody Islet1 antibody
Accession NoSwiss-Prot#:P61371
Uniprot
P61371
Gene ID
3670;
Calculated MW39 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
ICC: 1:50-1:200
Western blot analysis of Islet 1 on MCF-7 cell lysates using anti-Islet 1 antibody at 1/1,000 dilution.
ICC staining Islet 1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Islet-1 (ISL1 transcription factor, LIM/homeodomain) and Islet-2 (ISL2 transcription factor, LIM/homeodomain) contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner.
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