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Location： Home > Recombinant Rabbit Monoclonal Antibodies > alpha 1 Catenin Rabbit mAb

alpha 1 Catenin Rabbit mAb#48960

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Product Detail

Product Namealpha 1 Catenin Rabbit mAb

Clone No.SC0619

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesAlpha E-catenin antibody
Cadherin associated protein 102kDa antibody
Cadherin associated protein antibody
Cadherin-associated protein antibody
CAP 102 antibody
CAP102 antibody
Catenin (cadherin associated protein) alpha 1 102kDa antibody
Catenin (cadherin associated protein), alpha 1, 102kDa antibody
Catenin alpha 1 antibody
Catenin alpha-1 antibody
CTNA1_HUMAN antibody
CTNNA 1 antibody
Ctnna1 antibody
FLJ36832 antibody
FLJ52416 antibody
NY REN 13 antigen antibody
OTTHUMP00000224141 antibody
OTTHUMP00000224147 antibody
Renal carcinoma antigen NY REN 13 antibody
Renal carcinoma antigen NY-REN-13 antibody

Accession NoSwiss-Prot#:P35221

Uniprot P35221

Gene ID 1495;

Calculated MW100 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100
Western blot analysis of alpha 1 Catenin on different lysates using anti-alpha 1 Catenin antibody at 1/1,000 dilution. Positive control:
Lane 1: Hela
Lane 2: HepG2
Lane 3: A431
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-alpha 1 Catenin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-alpha 1 Catenin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-alpha 1 Catenin antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Hela cells with alpha 1 Catenin antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
α E-catenin (also designated α-catenin; cadherin-associated protein, α1, 102 kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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