Product Detail
Product NameCaspase-6 p18 Rabbit mAb
Clone No.SN07-26
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesApoptotic protease Mch-2 antibody Apoptotic protease MCH2 antibody CASP-6 antibody CASP6 antibody CASP6_HUMAN antibody Caspase 6 antibody Caspase 6 apoptosis related cysteine protease antibody Caspase 6, apoptosis related cysteine peptidase antibody Caspase-6 subunit p11 antibody Caspase-6 subunit p20 antibody Mch2 antibody OTTHUMP00000162742 antibody OTTHUMP00000162743 antibody
Accession NoSwiss-Prot#:P55212
Uniprot
P55212
Gene ID
839;
Calculated MW18/33 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-5,000
Western blot analysis of Caspase-6 p18 on U937 cells lysates using anti-Caspase-6 p18 antibody at 1/1,000 dilution.
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
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