Product Detail
Product NameLSP1 Rabbit mAb
Clone No.SN06-25
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names47 kDa actin binding protein antibody 47 kDa actin-binding protein antibody 52 kDa phosphoprotein antibody F actin binding and cytoskeleton associated protein antibody Leufactin (leukocyte F-actin binding protein) antibody Leufactin antibody Leukocyte F actin binding protein antibody Leukocyte specific protein 1 antibody LSP 1 antibody Lsp1 antibody LSP1_HUMAN antibody Lymphocyte specific antigen WP34 antibody Lymphocyte specific protein 1 antibody Lymphocyte specific protein pp52 antibody Lymphocyte-specific antigen WP34 antibody Lymphocyte-specific protein 1 antibody OTTHUMP00000014138 antibody OTTHUMP00000014139 antibody OTTHUMP00000014140 antibody OTTHUMP00000069612 antibody OTTHUMP00000069614 antibody OTTHUMP00000069615 antibody OTTHUMP00000069616 antibody pp52 antibody Protein pp52 antibody S37 protein antibody WP 34 antibody WP34 antibody
Accession NoSwiss-Prot#:P33241
Uniprot
P33241
Gene ID
4046;
Calculated MW52 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of LSP1 on Daudi cells lysates using anti-LSP1 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-LSP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse thymus tissue using anti-LSP1 antibody. Counter stained with hematoxylin.
pp52 (human) or LSP1 (murine) is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.
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