Product Detail
Product NameCdk8 Rabbit mAb
Clone No.SN2030
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Namescdk8 antibody CDK8 protein kinase antibody CDK8_HUMAN antibody Cell Division Kinase 8 antibody Cell division protein kinase 8 antibody Cyclin Dependent kinase 8 antibody Cyclin-dependent kinase 8 antibody K35 antibody Mediator complex subunit cdk8 antibody Mediator of RNA polymerase II transcription subunit cdk8 antibody Protein kinase K35 antibody
Accession NoSwiss-Prot#:P49336
Uniprot
P49336
Gene ID
1024;
Calculated MW53 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of Cdk8 on NIH/3T3 cells lysates using anti-Cdk8 antibody at 1/1,000 dilution.
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1C3, PITALRE and PITSLRE. Large complexes containing Cdk8, cyclin C and the large subunit of RNA polymerase II have been identified. Cdk8 is thought to regulate RNA polymerase II function in conjunction with cyclin C. Cdk8 has been demonstrated to function as a transcriptional activator when fused to the DNA binding domain of GAL4.
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