Product Detail
Product NameFOXO4 Rabbit mAb
Clone No.SD0817
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAFX antibody AFX1 antibody Afxh antibody ALL1-fused gene from X chromosome antibody Fork head domain transcription factor AFX1 antibody Forkhead box O4 antibody Forkhead box protein O4 antibody FOXO 4 antibody Foxo4 antibody FOXO4_HUMAN antibody MGC117660 antibody MGC120490 antibody Mixed lineage leukemia, translocated to, 7 antibody MLLT7 antibody Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 antibody Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody RGD1561201 antibody
Accession NoSwiss-Prot#:P98177
Uniprot
P98177
Gene ID
4303;
Calculated MW54/48 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
Western blot analysis of FOXO4 on human lung lysates using anti-FOXO4 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-FOXO4 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-FOXO4 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-FOXO4 antibody. Counter stained with hematoxylin.
FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serine-proline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t(x;11) translocation of the AFX1 gene, which involves the fusion of a serine-proline-rich sequence of AFX1 to the carboxy terminus of a truncated MLL, results in acute lymphocytic leukemia.
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