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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Sumo 2+3 Rabbit mAb

Sumo 2+3 Rabbit mAb#49224

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Product Detail

Product NameSumo 2+3 Rabbit mAb

Clone No.JJ087-04

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesHSMT3 antibody
MGC117191 antibody
OTTHUMP00000115275 antibody
OTTHUMP00000115276 antibody
OTTHUMP00000115277 antibody
Sentrin 2 antibody
Small ubiquitin like modifier 2 antibody
Small ubiquitin related modifier 2 antibody
small ubiquitin-like modifier 3 antibody
small ubiquitin-related modifier 3 antibody
SMT3 homolog 1 antibody
SMT3 homolog 2 antibody
SMT3 suppressor of mif two 3 homolog 1 antibody
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) antibody
SMT3 suppressor of mif two 3 homolog 2 antibody
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) antibody
SMT3 suppressor of mif two 3 homolog 3 antibody
SMT3A antibody
SMT3B antibody
SMT3H1 antibody
SMT3H2 antibody
Sumo2 antibody
Sumo3 antibody
Ubiquitin like protein SMT3A antibody
Ubiquitin like protein SMT3B antibody

Accession NoSwiss-Prot#:P55854

Uniprot P55854

Gene ID 6612;

Calculated MW12 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Western blot analysis of Sumo 2+3 on SW480 cells lysates using anti- Sumo 2+3 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti- Sumo 2+3 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti- Sumo 2+3 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti- Sumo 2+3 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti- Sumo 2+3 antibody. Counter stained with hematoxylin.
ICC staining Sumo 2+3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Sumo 2+3 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Sumo 2+3 in RH-35 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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