Product Detail
Product NameSIRT2 Rabbit mAb
Clone No.JJ08-83
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB
Species ReactivityHu, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesFLJ35621 antibody FLJ37491 antibody NAD dependent deacetylase sirtuin 2 antibody NAD-dependent deacetylase sirtuin-2 antibody NAD-dependent protein deacetylase sirtuin-2 antibody Regulatory protein SIR2 homolog 2 antibody Silencing information regulator 2 like antibody Silent information regulator 2 antibody SIR2 antibody SIR2 like protein 2 antibody Sir2 related protein type 2 antibody SIR2, S. cerevisiae, homolog-loke 2 antibody SIR2-like protein 2 antibody SIR2L antibody SIR2L2 antibody SIRT2 antibody SIRT2_HUMAN antibody Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae) antibody Sirtuin 2 antibody Sirtuin type 2 antibody
Accession NoSwiss-Prot#:Q8IXJ6
Uniprot
Q8IXJ6
Gene ID
22933;
Calculated MW43 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of SIRT2 on human brain lysates using anti-SIRT2 antibody at 1/1,000 dilution.
The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in a NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis.
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