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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Cystatin C Rabbit mAb

Cystatin C Rabbit mAb#49285

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Product Detail

Product NameCystatin C Rabbit mAb

Clone No.JJ09-16

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesAD 8 antibody
AD8 antibody
Amyloid angiopathy and cerebral hemorrhage antibody
ARMD11 antibody
bA218C14.4 (cystatin C) antibody
bA218C14.4 antibody
Cst 3 antibody
Cst3 antibody
CST3 protein antibody
Cystatin 3 antibody
Cystatin-3 antibody
Cystatin-C antibody
Cystatin3 antibody
CystatinC antibody
CYTC_HUMAN antibody
Epididymis secretory protein Li 2 antibody
Gamma trace antibody
Gamma-trace antibody
HCCAA antibody
HEL S 2 antibody
MGC117328 antibody
Neuroendocrine basic polypeptide antibody
Post gamma globulin antibody
Post-gamma-globulin antibody

Accession NoSwiss-Prot#:P01034

Uniprot P01034

Gene ID 1471;

Calculated MW16 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200


Western blot analysis of Cystatin C on different lysates using anti-Cystatin C antibody at 1/1,000 dilution. Positive control:
Lane 1: Hela
Lane 2: Mouse spleen
Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Cystatin C antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Cystatin C antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Cystatin C antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-Cystatin C antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Cystatin C antibody. Counter stained with hematoxylin.
Cystatin C is a cysteine (thiol) protease inhibitor that belongs to the type II cystatin gene superfamily and is the most abundant extracellular inhibitor of cysteine proteases. Cystatin C is a constitutively secreted, amyloidogenic protein, which forms a two-fold symmetric dimer and modulates both cysteine protease activity and the expression of class II MHC molecules. Expression of cystatin C is an indicator of kidney function and glomerular filtration rate. Mutations in the cystatin C gene can lead to protein aggregates, which are implicated in hereditary amyloid angiopathy (HCCAA) and cerebral hemorrhage. Although both wild-type and mutant cystatin C are capable of forming concentration dependent inactive dimers, mutant cystatin C dimerizes at lower concentrations and is more susceptible to serine proteases, which may facilitate aggregation. In neuronal cells, oxidative stress stimulates expression of cystatin C, which may positively regulate apoptosis.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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