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LAMP1 Rabbit mAb#49309

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Product Detail

Product NameLAMP1 Rabbit mAb

Clone No.SR4550

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB IHC

Species ReactivityHu

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesCD107 antigen like family member A antibody
CD107 antigen-like family member A antibody
CD107a antibody
CD107a antigen antibody
LAMP 1 antibody
LAMP-1 antibody
LAMP1 antibody
LAMP1_HUMAN antibody
LAMPA antibody
LGP120 antibody
lgpA antibody
Lysosomal membrane glycoprotein 120KD antibody
Lysosomal Associated Membrane Protein 1 antibody
Lysosome associated membrane glycoprotein 1 antibody
Lysosome-associated membrane glycoprotein 1 antibody
Lysosome-associated membrane protein 1 antibody
OTTHUMP00000040663 antibody

Accession NoSwiss-Prot#:P11279

Uniprot P11279

Gene ID 3916;

Calculated MWPredicted band size: 45 kDa

Sdspage MWObserved band size: 110-130

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:2000
IHC: 1:50-1:200
All lanes: LAMP1 Rabbit mAb at 1/1k dilution

Lane 1 : Hela whole cell lysates
Lane 2 : JK whole cell lysates
Lane 3 : MCF7 whole cell lysates
Lysates/proteins at 20 µg per lane.

Secondary
All lanes : Goat Anti-Rabbit IgG H&L (HRP) at 1/20000 dilution

Predicted band size: 45 kDa
Observed band size: 110-130 kDa

Exposure time: 7 seconds
All lanes:LAMP1 Rabbit mAb at 1/1k dilution

Lane 1 : Wild-type HCT116 cell lysate
Lane 2 : LAMP1 knockdown HCT116 cell lysate

Lysates/proteins at 20 µg per lane.
Formalin-fixed, paraffin-embedded human kidney tissue stained for LAMP1 using 49309 at 1/100 dilution in immunohistochemical analysis.

Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

If you have published an article using product 49309, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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