Product Detail
Product Namec-Fos Rabbit mAb
Clone No.JJ0938
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesActivator protein 1 antibody AP 1 antibody C FOS antibody Cellular oncogene c fos antibody Cellular oncogene fos antibody FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody FBJ murine osteosarcoma viral oncogene homolog antibody FBJ murine osteosarcoma viral v fos oncogene homolog antibody FBJ Osteosarcoma Virus antibody FOS antibody FOS protein antibody FOS_HUMAN antibody G0 G1 switch regulatory protein 7 antibody G0/G1 switch regulatory protein 7 antibody G0S7 antibody Oncogene FOS antibody p55 antibody proto oncogene c Fos antibody Proto oncogene protein c fos antibody Proto-oncogene c-Fos antibody v fos FBJ murine osteosarcoma viral oncogene homolog antibody
Accession NoSwiss-Prot#:P01100
Uniprot
P01100
Gene ID
2353;
Calculated MW62 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
FC: 1:50-1:100
Flow cytometric analysis of NIH/3T3 cells with c-Fos antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
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et al,Curcumin induces apoptosis and inhibits the growth of adrenocortical carcinoma: Identification of potential candidate genes and pathways by transcriptome analysis. In Oncol Lett on 2021 Jun by Xuemei Huang, Chunfeng Liang,et al..PMID:33907586
, (2021),
PMID:
33907586
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