Product Detail
Product NameCollagen X Rabbit mAb
Clone No.JF0961
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCOAA1_HUMAN antibody Col10a 1 antibody COL10A1 antibody Collagen alpha 1(X) chain antibody Collagen alpha-1(X) chain antibody Collagen type X alpha 1 (Schmid metaphyseal chondrodysplasia) antibody Collagen type X alpha 1 antibody Collagen X alpha 1 polypeptide antibody CollagenX antibody fa66d11 antibody fb10c08 antibody OTTHUMP00000040411 antibody Procollagen type X alpha 1 antibody Schmid metaphyseal chondrodysplasia antibody wu:fa66d11 antibody wu:fb10c08 antibody
Accession NoSwiss-Prot#:Q03692
Uniprot
Q03692
Gene ID
1300;
Calculated MW66 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of Collagen X on human skin lysates using anti-Collagen X antibody at 1/1,000 dilution.
Collagen Type X is associated with hypertrophic chondrocytes of avian and mammalian growth plate tissues during the endochondral growth of long bones. It is a component of normal articular cartilage in adult human, growing pig and newborn rat, and it is also present during any disruption of normal metabolic status of articular cartilage that occur with osteoarthritis. Collagen Type X is composed of three identical a 1(X) chains, each containing a triple-helical region flanked by a short N-terminal sequence and a larger non-collagenous C-terminal (NC1) domain. Mutations in COL10A1, the gene encoding for Collagen Type X, are associated with metaphyseal dysplasia type Schmid (SMCD) and other related forms of metaphyseal dysplasia. SMCD is characterized by short-limbed dwarfism, an outward "flaring" of the lower rib cage, bowed legs, leg pain and a hip deformity that causes the thigh bone to angle toward the center of the body.
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