Product Detail
Product NameFOXP3 Rabbit mAb
Clone No.JF0926
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAIID antibody DIETER antibody Forkhead box P3 antibody Forkhead box protein P3 antibody FOXP3 antibody FOXP3_HUMAN antibody FOXP3delta7 antibody Immune dysregulation polyendocrinopathy enteropathy X linked antibody Immunodeficiency polyendocrinopathy enteropathy X linked antibody IPEX antibody JM2 antibody MGC141961 antibody MGC141963 antibody OTTHUMP00000025832 antibody OTTHUMP00000025833 antibody OTTHUMP00000226737 antibody PIDX antibody Scurfin antibody XPID antibody
Accession NoSwiss-Prot#:Q9BZS1
Uniprot
Q9BZS1
Gene ID
50943;
Calculated MW50 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
FC: 1:10-1:50
Flow cytometric analysis of Raji cells with FOXP3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1, and the gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
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