Product Detail
Product NameHMGCR Rabbit mAb
Clone No.JF0981
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names3 hydroxy 3 methylglutaryl CoA reductase antibody 3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody 3 hydroxymethylglutaryl CoA reductase antibody 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody 3H3M antibody HMDH_HUMAN antibody HMG CoA reductase antibody HMG CoAR antibody HMG-CoA reductase antibody Hmgcr antibody Hydroxymethylglutaryl CoA reductase antibody LDLCQ3 antibody MGC103269 antibody Red antibody
Accession NoSwiss-Prot#:P04035
Uniprot
P04035
Gene ID
3156;
Calculated MW97 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
Western blot analysis of HMGCR on Hela cells lysates using anti-HMGCR antibody at 1/1,000 dilution.
The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.
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