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Location： Home > Recombinant Rabbit Monoclonal Antibodies > FOXP1 Rabbit mAb

FOXP1 Rabbit mAb#49358

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Product Detail

Product NameFOXP1 Rabbit mAb

Clone No.JF1017

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Names12CC4 antibody
FLJ23741 antibody
Fork head related protein like B antibody
Forkhead box P1 antibody
Forkhead box protein P1 antibody
FOX P1 antibody
FOXP 1 antibody
foxp1 antibody
FOXP1_HUMAN antibody
Glutamine rich factor 1 antibody
hFKH1B antibody
HSPC215 antibody
MGC12942 antibody
MGC88572 antibody
MGC99551 antibody
QRF 1 antibody
QRF1 antibody

Accession NoSwiss-Prot#:Q9H334

Uniprot Q9H334

Gene ID 27086;

Calculated MW77/75 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-5,000
IHC: 1:50-1:200


FC: 1:50-1:100
Western blot analysis of FOXP1 on different lysates using anti-FOXP1 antibody at 1/1,000 dilution. Positive control:
Lane 1: Hela
Lane 2: Jurkat
Lane 3: MCF-7
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-FOXP1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-FOXP1 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of MCF-7 cells with FOXP1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1. The gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23-Xq13.3. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T-cell activation.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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