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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Parkin Rabbit mAb

Parkin Rabbit mAb#49374

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Product Detail

Product NameParkin Rabbit mAb

Clone No.JF82-09

Host SpeciesRecombinant Rabbit

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesAR JP antibody
E3 ubiquitin ligase antibody
E3 ubiquitin protein ligase parkin antibody
E3 ubiquitin-protein ligase parkin antibody
FRA6E antibody
LPRS 2 antibody
LPRS2 antibody
PARK 2 antibody
Park2 antibody
Parkin 2 antibody
Parkinson disease (autosomal recessive juvenile) 2 antibody
Parkinson disease (autosomal recessive, juvenile) 2, parkin antibody
Parkinson disease protein 2 antibody
Parkinson juvenile disease protein 2 antibody
Parkinson protein 2 E3 ubiquitin protein ligase antibody
Parkinson protein 2, E3 ubiquitin protein ligase (parkin) antibody
PDJ antibody
PRKN 2 antibody
PRKN antibody
PRKN2 antibody
PRKN2_HUMAN antibody
Ubiquitin E3 ligase PRKN antibody

Accession NoSwiss-Prot#:O60260

Uniprot O60260

Gene ID 5071;

Calculated MW52 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
ICC: 1:50-1:200
IP: 1:50
FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-Parkin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Parkin antibody. Counter stained with hematoxylin.
ICC staining Parkin in N2A cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Parkin in SH-SY-5Y cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining Parkin in PC-3M cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of SH-SY-5Y cells with Parkin antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. The wild type Parkin gene, which maps to human chromosome 6q25.2-27, encodes a 465 amino acid full-length protein that is expressed as multiple isoforms. Mutations in the Parkin gene are responsible for autosomal recessive juvenile Parkinson's disease and commonly involve deletions of exons 3-5. In humans, Parkin is expressed in a subset of cells of the basal ganglia, midbrain, cerebellum and cerebral cortex, and is subject to alternative splicing in different tissues. Parkin expression is also high in the brainstem of mice, with the majority of immunopositive cells being neurons. The Parkin gene has been identified in a diverse group of organisms including mammals, birds, frog and fruit flies, suggesting that analogous functional roles of the Parkin protein may have been highly conserved during the course of evolution.

If you have published an article using product 49374, please notify us so that we can cite your literature.

et al,Mitochondrial damage-induced abnormal glucose metabolism with ageing in the hippocampus of APP/PS1 miceInMetabolomicsOn2023 Jun 8byShijie Li?1?2,?Yangyang Wang et al..PMID:?37289288 , (2023),
PMID: 37289288

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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