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Location： Home > Recombinant Rabbit Monoclonal Antibodies > ADAM17 Rabbit mAb

ADAM17 Rabbit mAb#49419

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Product Detail

Product NameADAM17 Rabbit mAb

Clone No.JM10-35

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesA disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) antibody
A disintegrin and metalloproteinase domain 17 antibody
ADA17_HUMAN antibody
ADAM 17 antibody
ADAM metallopeptidase domain 17 antibody
ADAM17 antibody
ADAM17 protein antibody
CD 156b antibody
CD156b antibody
CD156b antigen antibody
CSVP antibody
Disintegrin and metalloproteinase domain-containing protein 17 antibody
MGC71942 antibody
NISBD antibody
NISBD1 antibody
Snake venom like protease antibody
Snake venom-like protease antibody
TACE antibody
TNF alpha convertase antibody
TNF alpha converting enzyme antibody
TNF-alpha convertase antibody
TNF-alpha-converting enzyme antibody
Tumor Necrosis Factor Alpha Converting Enzyme antibody

Accession NoSwiss-Prot#:P78536

Uniprot P78536

Gene ID 6868;

Calculated MW93 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000

ICC: 1:50-1:200
IP: 1:50
FC: 1:50-1:100
Western blot analysis of ADAM17 on Jurkat cells lysates using anti-ADAM17 antibody at 1/1,000 dilution.
ICC staining ADAM17 in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ADAM17 in SKOV-3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ADAM17 in SW480 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Hela cells with ADAM17 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Tumor necrosis factor β (TNFβ), also known as lymphotoxin, is a pleiotropic cytokine. TNFα, also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNFβ. TNFβ and TNFα share 30% amino acid homology and have similar biological activities. TNFβ is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFα is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFβ and TNFα can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFα converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFα precursor to release soluble TNFα.

If you have published an article using product 49419, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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