Product Detail
Product NameNOTCH4 Rabbit mAb
Clone No.JM101-05
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu, Ms
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesFLJ16302 antibody
hNotch 4 antibody
hNotch4 antibody
INT3 antibody
Neurogenic locus notch homolog protein 4 antibody
NOTC4_HUMAN antibody
Notch 4 antibody
Notch 4 intracellular domain antibody
Notch homolog 4 antibody
NOTCH3 antibody
Notch4 antibody
NOTCH4 protein antibody
Accession NoSwiss-Prot#:Q99466
Uniprot
Q99466
Gene ID
4855;
Calculated MW210 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.06% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
FC: 1:50-1:100
Flow cytometric analysis of Hela cells with NOTCH4 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
The LIN-12/Notch transmembrane receptors are believed to play a central role in development by regulating cell fate decisions. Four Notch homologs (Notch 1, Notch 2, Notch 3 and Notch 4) have been identified in mammals. The Notch genes are expressed in a variety of embryonic and adult tissues, suggesting that the genes are involved in multiple signaling pathways. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged1 can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 may be involved in tissue development that is dependent upon epithelial-mesenchymal interactions. In addition to its normal expression in the adrenal gland and placenta, Delta expression has also been found in neuroendocrine tumors.
If you have published an article using product 49433, please notify us so that we can cite your literature.
Yes
