Product Detail
Product NameGAD67 Rabbit mAb
Clone No.JM11-11
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names67 kDa glutamic acid decarboxylase antibody
CPSQ1 antibody
DCE1 antibody
DCE1_HUMAN antibody
EC 4.1.1.15 antibody
FLJ45882 antibody
GAD 67 antibody
GAD antibody
GAD-67 antibody
GAD1 antibody
Glutamate decarboxylase 1 (brain, 67kDa) antibody
Glutamate decarboxylase 1 antibody
Glutamate decarboxylase 1 brain 67kD antibody
Glutamate decarboxylase 1 brain 67kDa antibody
Glutamate decarboxylase 67 kDa isoform antibody
Glutamate decarboxylase, brain, 67-KD antibody
OTTHUMP00000041055 antibody
SCP antibody
Accession NoSwiss-Prot#:Q99259
Uniprot
Q99259
Gene ID
2571;
Calculated MW67 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
IP: 1:50-1:100
Western blot analysis of GAD67 on Hela cells lysates using anti-GAD67 antibody at 1/500 dilution.
There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (g-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues.
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