Product Detail
Product NameAromatase Rabbit mAb
Clone No.JM10-68
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB,IP
Species ReactivityHu, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesARO antibody
ARO1 antibody
Aromatase antibody
CP19A_HUMAN antibody
CPV1 antibody
CYAR antibody
CYP19 antibody
Cyp19a1 antibody
CYPXIX antibody
Cytochrome P-450AROM antibody
Cytochrome P450 19A1 antibody
Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody
Cytochrome P450, subfamily XIX (aromatization of androgens) antibody
Estrogen synthase antibody
Estrogen synthetase antibody
Flavoprotein linked monooxygenase antibody
MGC104309 antibody
Microsomal monooxygenase antibody
OTTHUMP00000162543 antibody
OTTHUMP00000198350 antibody
P 450AROM antibody
Accession NoSwiss-Prot#:P11511
Uniprot
P11511
Gene ID
1588;
Calculated MW58 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IP: 1:10-1:50
Western blot analysis of Aromatase on different cells lysates using anti-Aromatase antibody at 1/500 dilution. Positive control: Lane 1: JAR Lane 2: Jurkat
P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endogenous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. Other P450 family members include CYP19, also designated aromatase (P450arom), which catalyzes the conversion of C19 steroids to estrogens in various tissues, including placenta, gonads, adipose tissue, skin and brain. CYP19 expression is controlled by hormonally regulated promoters in different tissues and increased CYP19 activity is associated with familial gynecomastia. Also, a polymorphic allele of CYP19 (repeat (TTTA)12) is present in a majority of breast cancer patients. P450 cholesterol 7α-hydroxylase, CYP7A1, is the rate-limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D3 25-hydroxylation and is localized to the mitochondria in kidney and liver.
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