Product Detail
Product NameKu 70 Rabbit mAb
Clone No.JM61-31
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP, ICC/IF, IHC, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names5''-deoxyribose-5-phosphate lyase Ku70 antibody
5''-dRP lyase Ku70 antibody
70 kDa subunit of Ku antigen antibody
ATP dependent DNA helicase 2 subunit 1 antibody
ATP dependent DNA helicase II 70 kDa subunit antibody
ATP-dependent DNA helicase 2 subunit 1 antibody
ATP-dependent DNA helicase II 70 kDa subunit antibody
CTC box binding factor 75 kDa subunit antibody
CTC box-binding factor 75 kDa subunit antibody
CTC75 antibody
CTCBF antibody
DNA repair protein XRCC6 antibody
G22P1 antibody
Ku 70 antibody
Ku autoantigen p70 subunit antibody
Ku autoantigen, 70kDa antibody
Ku p70 antibody
Ku70 antibody
Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody
Kup70 antibody
Lupus Ku autoantigen protein p70 antibody
ML8 antibody
Thyroid autoantigen 70kD (Ku antigen) antibody
Thyroid autoantigen antibody
Thyroid lupus autoantigen antibody
Thyroid lupus autoantigen p70 antibody
Thyroid-lupus autoantigen antibody
TLAA antibody
X ray repair complementing defective repair in Chinese hamster cells 6 antibody
X-ray repair complementing defective repair in Chinese hamster cells 6 antibody
X-ray repair cross-complementing protein 6 antibody
XRCC 6 antibody
Xrcc6 antibody
XRCC6_HUMAN antibody
Accession NoSwiss-Prot#:P12956
Uniprot
P12956
Gene ID
2547;
Calculated MW70 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
IP: 1:10-1:50
FC: 1:50-1:100
The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (p70) and Ku-86 (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer 1 binding factor (E1BF), composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.
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