Product Detail
Product NameDCAMKL1 Rabbit mAb
Clone No.JA11-03
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCalcium/calmodulin-dependent protein kinase type I-like CPG16 antibody
CL1 antibody
CLICK1 antibody
Cpg16 antibody
DCDC3A antibody
Dcl antibody
Dclk antibody
Dclk1 antibody
DCLK1_HUMAN antibody
Doublecortin domain-containing protein 3A antibody
Doublecortin-like and CAM kinase-like 1 antibody
Doublecortin-like kinase 1 antibody
KIAA0369 antibody
Serine/threonine-protein kinase DCAMKL1 antibody
Serine/threonine-protein kinase DCLK1 antibody
Accession NoSwiss-Prot#:O15075
Uniprot
O15075
Gene ID
9201;
Calculated MW82 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to β-subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortinlike and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.
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