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Location： Home > Recombinant Rabbit Monoclonal Antibodies > PRMT1 Rabbit mAb

PRMT1 Rabbit mAb#49531

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Product Detail

Product NamePRMT1 Rabbit mAb

Clone No.JA11-17

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, CHIP

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesANM 1 antibody
ANM1 antibody
ANM1_HUMAN antibody
HCP 1 antibody
HCP1 antibody
Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody
Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody
Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody
Histone-arginine N-methyltransferase PRMT1 antibody
HMT 2 antibody
HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody
HMT1 hnRNP methyltransferase antibody
HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody
HMT1 hnRNP methyltransferase like 2 antibody
HMT2 antibody
HRMT1 L2 antibody
HRMT1L 2 antibody
HRMT1L2 antibody
Human mRNA for suppressor for yeast mutant antibody
Human mRNA for suppressor for yeast mutant complete cds antibody
Interferon receptor 1 bound protein 4 antibody
Interferon receptor 1 bound protein4 antibody
Interferon receptor 1-bound protein 4 antibody
Interferon receptor 1bound protein 4 antibody
IR1 B4 antibody
IR1B 4 antibody
IR1B4 antibody
Mrmt 1 antibody
Mrmt1 antibody
PRMT 1 antibody
PRMT1 antibody
Protein arginine methyltransferase 1 antibody
Protein arginine N methyltransferase 1 antibody
Protein arginine N methyltransferase1 antibody
Protein arginine N-methyltransferase 1 antibody
R1B4 antibody
S. cerevisiae like 2 antibody

Accession NoSwiss-Prot#:Q99873

Uniprot Q99873

Gene ID 3276;

Calculated MW42 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
ICC: 1:100-1:500

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-PRMT1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-PRMT1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-PRMT1 antibody. Counter stained with hematoxylin.
ICC staining PRMT1 in D3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PRMT1 in NIH-3T3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PRMT1 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PRMT1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PRMT1 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMT1, the predominant form in mammalian cells, is located in the nucleus, while PRMT3 is present in the cytoplasm. At the carboxy-terminus, interleukin enhancer-binding factor 3 (ILF3) binds PRMT1, thereby regulating PRMT1 activitiy. Alternative mRNA splicing of the PRMT gene results in three isoforms of PRMT1 that differ in their amino-terminus regions. All three splice variants of PRMT1 are enzymatically active. PRMT3 recognizes and binds to RNA-associated substrates with a zinc-finger domain in its amino-terminus. The zinc-liganded form of this domain is required for the enzyme to recognize RNA-associated substrates.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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