Product Detail
Product NameSFRP1 Rabbit mAb
Clone No.JA11-68
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesFrizzled related protein 1 antibody
FRP 1 antibody
FRP antibody
FRP-1 antibody
FRP1 antibody
FrzA antibody
SARP 2 antibody
SARP-2 antibody
SARP2 antibody
Secreted apoptosis related protein 2 antibody
Secreted apoptosis-related protein 2 antibody
Secreted frizzled related protein 1 antibody
Secreted frizzled related protein antibody
Secreted frizzled-related protein 1 antibody
SFRP 1 antibody
sFRP-1 antibody
SFRP1 antibody
SFRP1_HUMAN antibody
Accession NoSwiss-Prot#:Q8N474
Uniprot
Q8N474
Gene ID
6422;
Calculated MW35 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
Western blot analysis of SFRP1 on human kidney cells lysates using anti-SFRP1 antibody at 1/500 dilution.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
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