Product Detail
Product NameCaMKII delta Rabbit mAb
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt, Zebrafish
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCalcium / calmodulin dependent protein kinase 2 delta antibody
Calcium / calmodulin dependent protein kinase II delta antibody
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta antibody
calcium/calmodulin-dependent protein kinase type II delta chain antibody
Calcium/calmodulin-dependent protein kinase type II subunit delta antibody
CAM kinase 2 delta antibody
CAM kinase II delta antibody
CaM kinase II delta subunit antibody
CaM kinase II subunit delta antibody
CaM-kinase II delta chain antibody
CAMK 2d antibody
CaMK-II delta subunit antibody
CaMK-II subunit delta antibody
CAMK2D antibody
CAMKD antibody
CAMKI antibody
KCC2D_HUMAN antibody
RATCAMKI antibody
Accession NoSwiss-Prot#:Q13557
Uniprot
Q13557
Gene ID
817;
Calculated MW50 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:50-1:200
Western blot analysis of CaMKII delta on Human skeletal muscle (1) and Rat heart (2) cells lysates using anti-CaMKII delta antibody at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded zebrafish tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-CaMKII delta antibody. Counter stained with hematoxylin.
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2influx into the myocyte, Ca2release from the sarcoplasmic reticulum (SR), SR Ca2uptake and Naand Kchannel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Regulates Ca2influx to myocytes by binding and phosphorylating the L-type Ca2channel subunit beta-2 CACNB2. In addition to Ca2channels, can target and regulate the cardiac sarcolemmal Nachannel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis.
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