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Location： Home > Recombinant Rabbit Monoclonal Antibodies > MRP2 Rabbit mAb

MRP2 Rabbit mAb#49557

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Product Detail

Product NameMRP2 Rabbit mAb

Clone No.JA32-01

Host SpeciesRecombinant Rabbit

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, ICC, IHC, FC

Species ReactivityHu

Immunogen DescSynthetic peptide within Human MRP2

ConjugateUnconjugated

Other NamesABC30 antibody
abcC2 antibody
ATP binding cassette sub family C (CFTR/MRP) member 2 antibody
ATP binding cassette subfamily C member 2 antibody
ATP-binding cassette sub-family C member 2 antibody
Canalicular multidrug resistance protein antibody
Canalicular multispecific organic anion transporter 1 antibody
CMOAT antibody
CMOAT1 antibody
cMRP antibody
DJS antibody
KIAA1010 antibody
MRP 2 antibody
MRP2_HUMAN antibody
Multidrug resistance associated protein 2 antibody
Multidrug resistance-associated protein 2 antibody

Accession NoSwiss-Prot#:Q92887

Uniprot Q92887

Gene ID 1244;

Calculated MW174 kDa

Concentration1ug/ul

Formulation1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB 1:2000;
IHC 1:50-1:800;
ICC 1:50-1:200;
FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-MRP2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-MRP2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-MRP2 antibody. Counter stained with hematoxylin.
ICC staining MRP2 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining MRP2 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of A549 cells with MRP2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
Western blot analysis of MRP2 on different lysates with MRP2 at 1/2,000 dilution.
Lane 1: HepG2 cell lysate
Lane 2: A549 cell lysate
Lane 3: HeLa cell lysate (negative)
Lysates/proteins at 15 ug/Lane.
Predicted band size: 174 kDa
Observed band size: 300 kDa
Exposure time: 5 minutes;
4-20% SDS-PAGE gel.
Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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