Product Detail
Product NameClathrin heavy chain Rabbit mAb
Clone No.JA53-02
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms,Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCHC17 antibody
Clathrin heavy chain antibody
Clathrin heavy chain 1 antibody
Clathrin heavy chain 2 antibody
Clathrin heavy chain like 1 antibody
Clathrin heavy chain on chromosome 17 antibody
Clathrin heavy polypeptide antibody
CLH 17 antibody
CLH 22 antibody
CLH-17 antibody
CLH1_HUMAN antibody
CLH17 antibody
CLH22 antibody
CLTC antibody
CLTCL antibody
CLTCL1 antibody
CLTCL2 antibody
CLTD antibody
Hc antibody
KIAA0034 antibody
Accession NoSwiss-Prot#:P53675
Uniprot
P53675
Gene ID
8218;
Calculated MW191/187 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:50-1:200
Western blot analysis of Clathrin heavy chain on Hela (1) and PC-12 (2) cell lysate using anti-Clathrin heavy chain antibody at 1/1,000 dilution.
Clathrin is a major cytosolic coat protein in pits and vesicles originating from the plasma membrane and the trans-Golgi network. In receptor-mediated endocytosis, receptor proteins are englufed by clathrin-coated vesicles. Clathrin is composed of three heavy chains and three light chains which associate non-covalently to form a triskelion structure. Clathrin heavy chain (HC) is composed of a terminal globular domain, a distal segment and a proximal segment containing a light chain binding site. The proximal segment of the Clathrin HC protein is essential for interactions between clathrin heavy chains and light chains which result in the formation of the triskelion structure.
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