Product Detail
Product Name5HT2C Receptor Rabbit mAb
Clone No.JA31-31
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names5 Hydroxytryptamine 2C receptor antibody
5-HT-1C antibody
5-ht-1c receptor antibody
5-HT-2C antibody
5-HT1C antibody
5-HT2C antibody
5-HTR2C antibody
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled antibody
5-hydroxytryptamine receptor 1C antibody
5-hydroxytryptamine receptor 2C antibody
5HT1C antibody
5HT2C antibody
5HT2C_HUMAN antibody
5HTR2C antibody
5Hydroxytryptamine 2C receptor antibody
Htr1c antibody
HTR2C antibody
serotonin 1c receptor antibody
serotonin 2c receptor antibody
Serotonin 5-HT-2C receptor antibody
Serotonin receptor 2C antibody
Accession NoSwiss-Prot#:P28335
Uniprot
P28335
Gene ID
3358;
Calculated MW70 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:50-1:200
Western blot analysis of 5HT2C Receptor on A431 (1) AND K562 (2) lysates using anti-5HT2C Receptor antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-5HT2C Receptor antibody. Counter stained with hematoxylin.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone.
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