Product Detail
Product NamePLGF Rabbit mAb
Clone No.JA63-15
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC, IHC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesD12S1900 antibody
Pgf antibody
PGFL antibody
PIGF antibody
Placenta growth factor antibody
Placental growth factor antibody
Placental growth factor, vascular endothelial growth factor related protein antibody
PlGF 2 antibody
PlGF antibody
PLGF_HUMAN antibody
PlGF2 antibody
SHGC 10760 antibody
Accession NoSwiss-Prot#:P49763
Uniprot
P49763
Gene ID
5228;
Calculated MW50 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
he onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Like VEGF, several PlGF variants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PlGF signaling. While VEGF homodimers and VEGF/PlGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PlGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PlGF. VEGF and PlGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.
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