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Location： Home > Recombinant Rabbit Monoclonal Antibodies > SHP2 Rabbit mAb

SHP2 Rabbit mAb#52027

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Product Detail

Product NameSHP2 Rabbit mAb

Clone No.S08-3G2

Host SpeciesRecombinant Rabbit

ClonalityMonoclonal

IsotypeRabbit IgG

PurificationAffinity Purified

ApplicationsWB IHC

Species ReactivityHuman

Immunogen DescA synthetic peptide of human SHP2

ConjugateUnconjugated

Other NamesCFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP

Accession NoSwiss-Prot:Q06124
GeneID:5781

Uniprot Q06124

Gene ID 5781

Calculated MWCalculated MW: 68 kDa; Observed MW: 68 kDa

Concentration0.3 mg/ml

Formulation50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

StorageStore at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

Application Details
WB: 1/2000; IHC: 1/20;
Western blot detection of SHP2 in Hela,293 cell lysates using SHP2 Rabbit mAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:68kDa.
Immunohistochemistry of SHP2 in paraffin-embedded Human breast cancer tissue using SHP2 Rabbit mAb at dilution 1/50
Swiss-Prot Acc.Q06124.Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).

If you have published an article using product 52027, please notify us so that we can cite your literature.

et al,Grass carp (Ctenopharyngodon idellus) SHP2 suppresses IFN I expression via decreasing the phosphorylation of GSK3 beta in a non-contact manner , (2021),
PMID: 34265416

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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