Product Detail
Product NameBANF1 Rabbit mAb
Clone No.S09-3F2
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
IsotypeRabbit IgG
PurificationAffinity Purified
ApplicationsWB
Species ReactivityHuman,Mouse,Rat
Immunogen DescA synthetic peptide of human BANF1
ConjugateUnconjugated
Other NamesBAF; BANF1; BCRG1; BCRP1; NGPS;
Accession NoSwiss-Prot:O75531
GeneID:8815
Uniprot
O75531
Gene ID
8815
Calculated MWCalculated MW: 10 kDa; Observed MW: 10 kDa
Concentration0.3 mg/ml
Formulation50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
StorageStore at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Application Details
WB: 1/1000-1/5000;
Western blot detection of BANF1 in Jurkat cell lysates using BANF1 Rabbit mAb(1:1000 diluted).Predicted band size:10kDa.Observed band size:10kDa.
Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:32792394).
Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (PubMed:9465049).
Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (PubMed:28841419).
Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (PubMed:28841419).
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